In the US, there are plenty of general geek cons that the Homestuck fandom will feel right at home as seen in the list:
http://en.wikipedia.org/wiki/Cat...ience_fiction_conventions with DragonCon and any of the ComicCon being the big ones.
It seems that even though many Homestuck fans overlap with anime, they seem to be met with disdain by some non-Homestuck, anime fan con-goes. Even more so than with any other previously popular Japanese franchise like Naruto of Hetalia, because it's a popular
American-originated comic. I'm not sure if they are met with that much bile in a general sci-fi/fantasy convention than ones that are about anime and Japanese video games.